Flavin-mediated photo-oxidation for the detection of mitochondrial flavins.
نویسندگان
چکیده
We report a new approach for the detection of mitochondrial flavins through photo-oxidation of a probe molecule. Probe 1 showed high brightness (ε × Φf = 6.50 × 103 M-1 cm-1) at long wavelengths (maximum emission wavelength, λmax = 600 nm) upon photo-oxidation, assisted by the strong electron accepting ability of the isoalloxazine moiety in flavins. Probe 1 also exhibited high selectivity for flavins over various biological oxidants, remarkable photo-stability, and mitochondrial localization.
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عنوان ژورنال:
- Chemical communications
دوره 52 92 شماره
صفحات -
تاریخ انتشار 2016